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Next, ethanol (8.6 ml) and potassium hydroxide (0.85 g, 13 mmol) were added to 3-(di-5-hexenyl)aminopropionitrile (2.0 g, 8.6 mmol), and the mixture was refluxed for 7.5 hours. The reaction mixture was allowed to stand, and then water (150 ml) and chloroform (150 ml) were added to the reaction mixture. Layers were separated, and the organic layer was dried over sodium sulfate. The organic layer was concentrated under reduced pressure, and the residue was purified by basic silica gel column chromatography to give 0.32 g (21%) of the titled compound as a pale yellow oily matter.

1. temperaturethe mixture was refluxed for 7.5 hours
2. customLayers were separated
3. dry with materialthe organic layer was dried over sodium sulfate
4. concentrationThe organic layer was concentrated under reduced pressure
5. customthe residue was purified by basic silica gel column chromatography