Bicarbonate Ion → tert-butyl 4-(2-(4-(trifluoromethyl)benzyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxamido)piperidine-1-carboxylate

HRID 114471Notes

Reaction equation

HRID 114471 reaction equation
[C:42]([O:43][BH-:44]([O:45][C:46](=[O:47])[CH3:48])[O:49][C:50](=[O:51])[CH3:52])(=[O:53])[CH3:54].[C:56](=[O:57])([OH:58])[O-:59].[CH2:1]1[NH:2][CH2:3][CH2:4][c:5]2[nH:6][c:7]3[cH:8][cH:9][c:10]([C:14](=[O:15])[NH:16][CH:17]4[CH2:18][CH2:19][N:20]([C:23](=[O:24])[O:25][C:26]([CH3:27])([CH3:28])[CH3:29])[CH2:21][CH2:22]4)[cH:11][c:12]3[c:13]21.[CH2:64]([O:65][CH2:66][CH3:67])[CH3:68].[Cl:61][CH2:62][Cl:63].[F:30][C:31]([c:32]1[cH:33][cH:34][c:35]([CH:36]=[O:37])[cH:38][cH:39]1)([F:40])[F:41].[Na+:55].[Na+:60]>>[CH2:1]1[N:2]([CH2:36][c:35]2[cH:34][cH:33][c:32]([C:31]([F:30])([F:40])[F:41])[cH:39][cH:38]2)[CH2:3][CH2:4][c:5]2[nH:6][c:7]3[cH:8][cH:9][c:10]([C:14](=[O:15])[NH:16][CH:17]4[CH2:18][CH2:19][N:20]([C:23](=[O:24])[O:25][C:26]([CH3:27])([CH3:28])[CH3:29])[CH2:21][CH2:22]4)[cH:11][c:12]3[c:13]21

Participants

8

Reactant 7

HCID 769Bicarbonate IonHCID 923Sodium ion2×HCID 3283Diethyl EtherHCID 6344DichloromethaneHCID 679964-(Trifluoromethyl)benzaldehydeHCID 2724942TriacetoxyborohydrideHCID 66589660HCID 66589660, compound

Product 1

HCID 44177408tert-butyl 4-(2-(4-(trifluoromethyl)benzyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxamido)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-288d39f4694f4595af642859ed460d75
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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