4-bromo-N-methylbenzene-1-sulfonamide → 4-[7-difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-N-methyl-benzenesulfonamide

HRID 114506Notes

Reaction equation

HRID 114506 reaction equation
[Br:25][c:26]1[cH:27][cH:28][c:29]([S:32](=[O:33])(=[O:34])[NH:35][CH3:36])[cH:30][cH:31]1.[F:1][CH:2]([c:3]1[cH:4][c:5](-[c:14]2[cH:15][cH:16][c:17]([C:20]([F:21])([F:22])[F:23])[cH:18][cH:19]2)[n:6][c:7]2[n:8]1[n:9][cH:10][c:11]2[C:12]#[CH:13])[F:24]>>[F:1][CH:2]([c:3]1[cH:4][c:5](-[c:14]2[cH:15][cH:16][c:17]([C:20]([F:21])([F:22])[F:23])[cH:18][cH:19]2)[n:6][c:7]2[n:8]1[n:9][cH:10][c:11]2[C:12]#[C:13][c:26]1[cH:27][cH:28][c:29]([S:32](=[O:33])(=[O:34])[NH:35][CH3:36])[cH:30][cH:31]1)[F:24]

Participants

3

Reactant 2

HCID 1012154-bromo-N-methylbenzene-1-sulfonamideHCID 866080343-Ethynyl-7-difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine

Product 1

HCID 670008934-[7-difluoromethyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-N-methyl-benzenesulfonamide

Sources & evidence

ORD record
ord-755cf29e6ac54dc6a2730e190d2879e5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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