Pyridine → 1-(2-(2-(5-bromo-pyridin-2-yl)-6-(4-methanesulfonyl-phenoxy)-3H-benzimidazol-5-yl)-pyrrolidin-1-yl)-ethanone

HRID 1145698Notes

Reaction equation

HRID 1145698 reaction equation
[Br:14][c:15]1[cH:16][cH:17][c:18](-[c:21]2[n:22][c:23]3[c:24]([nH:25]2)[cH:26][c:27]([CH:41]2[NH:42][CH2:43][CH2:44][CH2:45]2)[c:28]([O:30][c:31]2[cH:32][cH:33][c:34]([S:37](=[O:38])(=[O:39])[CH3:40])[cH:35][cH:36]2)[cH:29]3)[n:19][cH:20]1.[CH3:1][C:2](=[O:3])[O:4][C:5](=[O:6])[CH3:7].[CH:46]([Cl:47])([Cl:48])[Cl:49].[cH:8]1[cH:9][cH:10][n:11][cH:12][cH:13]1>>[CH3:1][C:2](=[O:3])[N:42]1[CH:41]([c:27]2[cH:26][c:24]3[c:23]([n:22][c:21](-[c:18]4[cH:17][cH:16][c:15]([Br:14])[cH:20][n:19]4)[nH:25]3)[cH:29][c:28]2[O:30][c:31]2[cH:32][cH:33][c:34]([S:37](=[O:38])(=[O:39])[CH3:40])[cH:35][cH:36]2)[CH2:45][CH2:44][CH2:43]1

Participants

5

Reactant 4

HCID 1049PyridineHCID 6212ChloroformHCID 7918Acetic AnhydrideHCID 231454112-(5-bromo-pyridin-2-yl)-5-(4-methanesulfonyl-phenoxy)-6-pyrrolidin-2-yl-1H-benzimidazole

Product 1

HCID 112498721-(2-(2-(5-bromo-pyridin-2-yl)-6-(4-methanesulfonyl-phenoxy)-3H-benzimidazol-5-yl)-pyrrolidin-1-yl)-ethanone

Sources & evidence

ORD record
ord-0fbffa33467445149106ca722c377bf7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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