Dichloromethane → N-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)phenyl)-3-(4-isopropyl piperazin-1-yl)propanamide

HRID 1145729Notes

Reaction equation

HRID 1145729 reaction equation
[CH:1]([CH3:2])([CH3:3])[N:4]1[CH2:5][CH2:6][N:7]([CH2:10][CH2:11][C:12](=[O:13])[NH:14][c:15]2[cH:16][c:17](-[c:21]3[n:22][c:23]4[cH:24][cH:25][cH:26][cH:27][c:28]4[c:29]([NH:31][c:32]4[cH:33][c:34]5[cH:35][n:36][n:37]([C:41]([O:42][C:43]([CH3:44])([CH3:45])[CH3:46])=[O:47])[c:38]5[cH:39][cH:40]4)[n:30]3)[cH:18][cH:19][cH:20]2)[CH2:8][CH2:9]1.[Cl:48][CH2:49][Cl:50]>>[CH:1]([CH3:2])([CH3:3])[N:4]1[CH2:5][CH2:6][N:7]([CH2:10][CH2:11][C:12](=[O:13])[NH:14][c:15]2[cH:16][c:17](-[c:21]3[n:22][c:23]4[cH:24][cH:25][cH:26][cH:27][c:28]4[c:29]([NH:31][c:32]4[cH:33][c:34]5[cH:35][n:36][nH:37][c:38]5[cH:39][cH:40]4)[n:30]3)[cH:18][cH:19][cH:20]2)[CH2:8][CH2:9]1

Participants

3

Reactant 2

HCID 6344DichloromethaneHCID 59361908tert-butyl 5-(2-(3-(3-(4-isopropylpiperazin-1-yl)propanamido)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

Product 1

HCID 11950893N-(3-(4-(1H-indazol-5-ylamino)quinazolin-2-yl)phenyl)-3-(4-isopropyl piperazin-1-yl)propanamide

Sources & evidence

ORD record
ord-fe99533f2ec3417aa1e755c2a4bfd9c6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

Loading…