1,3-Dimethyl-2-imidazolidinone → 3-[1-(6-Amino-pyrimidin-4-yl)-1H-benzoimidazol-2-ylamino]-4-methyl-N-[4-(2-methyl-imidazol-1-yl)-3-trifluoromethyl-phenyl]-benzamide

HRID 1147176Notes

Reaction equation

HRID 1147176 reaction equation
[CH3:45][N:46]1[CH2:47][CH2:48][N:49]([CH3:50])[C:51]1=[O:52].[Cl:1][c:2]1[n:3][c:4]2[c:5]([n:6]1-[c:7]1[cH:8][c:9]([NH2:13])[n:10][cH:11][n:12]1)[cH:14][cH:15][cH:16][cH:17]2.[NH2:18][c:19]1[cH:20][c:21]([C:22](=[O:23])[NH:24][c:25]2[cH:26][c:27]([C:37]([F:38])([F:39])[F:40])[c:28](-[n:31]3[c:32]([CH3:36])[n:33][cH:34][cH:35]3)[cH:29][cH:30]2)[cH:41][cH:42][c:43]1[CH3:44]>>[c:2]1([NH:18][c:19]2[cH:20][c:21]([C:22](=[O:23])[NH:24][c:25]3[cH:26][c:27]([C:37]([F:38])([F:39])[F:40])[c:28](-[n:31]4[c:32]([CH3:36])[n:33][cH:34][cH:35]4)[cH:29][cH:30]3)[cH:41][cH:42][c:43]2[CH3:44])[n:3][c:4]2[c:5]([n:6]1-[c:7]1[cH:8][c:9]([NH2:13])[n:10][cH:11][n:12]1)[cH:14][cH:15][cH:16][cH:17]2

Participants

4

Reactant 3

HCID 66611,3-Dimethyl-2-imidazolidinoneHCID 598224523-amino-4-methyl-N-[4-(2-methyl-imidazol-1-yl)-3-trifluoromethyl-phenyl]-benzamideHCID 598224556-(2-Chloro-benzoimidazol-1-yl)-pyrimidin-4-ylamine

Product 1

HCID 119908193-[1-(6-Amino-pyrimidin-4-yl)-1H-benzoimidazol-2-ylamino]-4-methyl-N-[4-(2-methyl-imidazol-1-yl)-3-trifluoromethyl-phenyl]-benzamide

Sources & evidence

ORD record
ord-9342150281d44c14a80995ed80015831
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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