Dichloromethane → 1-[4-(4-Amino-6-methylpyrrolo[2,1-f][1,2,4]triazin-5-yl)-2-fluorophenyl]-3-[4-(trifluoromethyl)pyridin-2-yl]urea

HRID 1148540Notes

Reaction equation

HRID 1148540 reaction equation
[Cl:38][CH2:39][Cl:40].[Cl:41][CH:42]([Cl:43])[CH3:44].[NH2:1][c:2]1[n:3][cH:4][n:5][n:6]2[c:7]1[c:8](-[c:13]1[cH:14][c:15]([F:33])[c:16]([NH:19][C:20](=[O:21])[NH:22][c:23]3[n:24][cH:25][cH:26][c:27]([C:29]([F:30])([F:31])[F:32])[cH:28]3)[cH:17][cH:18]1)[c:9]([CH2:11][OH:12])[cH:10]2.[S:34]([Cl:35])([Cl:36])=[O:37]>>[NH2:1][c:2]1[n:3][cH:4][n:5][n:6]2[c:7]1[c:8](-[c:13]1[cH:14][c:15]([F:33])[c:16]([NH:19][C:20](=[O:21])[NH:22][c:23]3[n:24][cH:25][cH:26][c:27]([C:29]([F:30])([F:31])[F:32])[cH:28]3)[cH:17][cH:18]1)[c:9]([CH3:11])[cH:10]2

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 63651,1-DichloroethaneHCID 24386Thionyl ChlorideHCID 57758291HCID 57758291, compound

Product 1

HCID 579552711-[4-(4-Amino-6-methylpyrrolo[2,1-f][1,2,4]triazin-5-yl)-2-fluorophenyl]-3-[4-(trifluoromethyl)pyridin-2-yl]urea

Sources & evidence

ORD record
ord-d579715725ba49f6a76ca5a99d1d0976
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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