3-(5-chloro-4-fluoro-2-hydroxyphenyl)-1-pentyl-1,3-dihydro-2H-indol-2-one → 3-(5-chloro-4-fluoro-2-hydroxyphenyl)-3-(hydroxymethyl)-1-pentyl-1,3-dihydro-2H-indol-2-one

HRID 1148679Notes

Reaction equation

HRID 1148679 reaction equation
[Br:1][c:2]1[cH:3][cH:4][cH:6][c:7]2[c:8]1[CH:9]([c:10]1[c:11]([OH:12])[cH:13][c:14]3[c:19]([cH:20]1)[O:18][CH2:17][O:15]3)[C:5](=[O:16])[N:21]2[CH2:22][CH2:23][CH2:24][CH2:25][CH3:26].[Cl:27][c:28]1[c:29]([F:50])[cH:30][c:31]([OH:49])[c:32]([CH:34]2[C:35](=[O:48])[N:36]([CH2:43][CH2:44][CH2:45][CH2:46][CH3:47])[c:37]3[cH:38][cH:39][cH:40][cH:41][c:42]32)[cH:33]1>>[CH2:5]([OH:16])[C:34]1([c:32]2[c:31]([OH:49])[cH:30][c:29]([F:50])[c:28]([Cl:27])[cH:33]2)[C:35](=[O:48])[N:36]([CH2:43][CH2:44][CH2:45][CH2:46][CH3:47])[c:37]2[cH:38][cH:39][cH:40][cH:41][c:42]21

Participants

3

Reactant 2

HCID 588724353-(5-chloro-4-fluoro-2-hydroxyphenyl)-1-pentyl-1,3-dihydro-2H-indol-2-oneHCID 588725004-bromo-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1-pentyl-1,3-dihydro-2H-indol-2-one

Product 1

HCID 588725173-(5-chloro-4-fluoro-2-hydroxyphenyl)-3-(hydroxymethyl)-1-pentyl-1,3-dihydro-2H-indol-2-one

Sources & evidence

ORD record
ord-91afb28d74224aba9d2c4613e2181de1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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