2-Chloro-6-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)pyridine → (1SR,3RS)-3-[3-(2-Chloro-6-fluoro-pyridin-4-yl)-imidazo[1,2-a]pyridin-6-ylamino)-cyclohexanol

HRID 1149422Notes

Reaction equation

HRID 1149422 reaction equation
[Br:42][c:43]1[n:44]2[cH:45][c:46]([NH:47][CH:48]3[CH2:49][CH2:50][CH2:51][CH:52]([OH:53])[CH2:54]3)[cH:55][cH:56][c:57]2[n:58][cH:59]1.[Cl:18][c:19]1[cH:20][c:21](-[c:25]2[cH:26][n:27][c:28]3[n:29]2[cH:30][c:31]([NH:34][CH:35]2[CH2:36][CH:37]([OH:41])[CH2:38][CH2:39][CH2:40]2)[cH:32][cH:33]3)[cH:22][cH:23][n:24]1.[Cl:1][c:2]1[n:3][c:4]([F:17])[cH:5][c:6]([B:8]2[O:9][C:10]([CH3:11])([CH3:12])[C:13]([CH3:14])([CH3:15])[O:16]2)[cH:7]1>>[Cl:1][c:2]1[n:3][c:4]([F:17])[cH:5][c:6](-[c:25]2[cH:26][n:27][c:28]3[n:29]2[cH:30][c:31]([NH:34][CH:35]2[CH2:36][CH:37]([OH:41])[CH2:38][CH2:39][CH2:40]2)[cH:32][cH:33]3)[cH:7]1

Participants

4

Reactant 3

HCID 467392412-Chloro-6-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)pyridineHCID 68483082(1RS,3RS)-3-(3-Bromo-imidazo[1,2-a]pyridin-6-ylamino)-cyclohexanolHCID 86644340(1SR,3RS)-3-[3-(2-Chloro-pyridin-4-yl)-imidazo[1,2-a]pyridin-6-ylamino)-cyclohexanol

Product 1

HCID 86644342(1SR,3RS)-3-[3-(2-Chloro-6-fluoro-pyridin-4-yl)-imidazo[1,2-a]pyridin-6-ylamino)-cyclohexanol

Sources & evidence

ORD record
ord-9297a096077b42e5ae19f04ccbe41da2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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