Pyridine → 6-(6-Chloro-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid [5-tert-butyl-2-(4-fluoro-phenyl)-2H-pyrazol-3-yl]-amide

HRID 1149603Notes

Reaction equation

HRID 1149603 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([NH2:17])[n:8](-[c:10]2[cH:11][cH:12][c:13]([F:16])[cH:14][cH:15]2)[n:9]1.[Cl:18][c:19]1[cH:20][c:21]([O:25][c:26]2[cH:27][c:28]3[cH:29][cH:30][cH:31][c:32]([C:36](=[O:37])[Cl:38])[c:33]3[cH:34][cH:35]2)[n:22][cH:23][n:24]1.[Cl:45][CH2:46][Cl:47].[cH:39]1[cH:40][cH:41][n:42][cH:43][cH:44]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[cH:6][c:7]([NH:17][C:36]([c:32]2[cH:31][cH:30][cH:29][c:28]3[cH:27][c:26]([O:25][c:21]4[cH:20][c:19]([Cl:18])[n:24][cH:23][n:22]4)[cH:35][cH:34][c:33]32)=[O:37])[n:8](-[c:10]2[cH:11][cH:12][c:13]([F:16])[cH:14][cH:15]2)[n:9]1

Participants

5

Reactant 4

HCID 1049PyridineHCID 6344DichloromethaneHCID 20605733-tert-butyl-1-(4-fluorophenyl)-1H-pyrazol-5-amineHCID 574551736-(6-Chloropyrimidin-4-yloxy)naphthalene-1-carbonyl chloride

Product 1

HCID 866386206-(6-Chloro-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid [5-tert-butyl-2-(4-fluoro-phenyl)-2H-pyrazol-3-yl]-amide

Sources & evidence

ORD record
ord-03354f6f3cca4c27914d3b29b078feca
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

Loading…