2-(Piperidin-4-yl)acetamide → 2-(1-(2-(4-(4-Acetylpiperazin-1-yl)phenylamino)-5-fluoropyrimidin-4-yl)piperidin-4-yl)acetamide

HRID 1149851Notes

Reaction equation

HRID 1149851 reaction equation
[NH2:1][CH2:2][CH:3]1[CH2:4][CH2:5][N:6]([c:9]2[n:10][c:11]([NH:16][c:17]3[cH:18][cH:19][c:20]([N:23]4[CH2:24][CH2:25][N:26]([C:29]([CH3:30])=[O:31])[CH2:27][CH2:28]4)[cH:21][cH:22]3)[n:12][cH:13][c:14]2[F:15])[CH2:7][CH2:8]1.[NH:32]1[CH2:33][CH2:34][CH:35]([CH2:36][C:39](=[O:40])[NH2:41])[CH2:37][CH2:38]1>>[CH2:2]([CH:3]1[CH2:4][CH2:5][N:6]([c:9]2[n:10][c:11]([NH:16][c:17]3[cH:18][cH:19][c:20]([N:23]4[CH2:24][CH2:25][N:26]([C:29]([CH3:30])=[O:31])[CH2:27][CH2:28]4)[cH:21][cH:22]3)[n:12][cH:13][c:14]2[F:15])[CH2:7][CH2:8]1)[C:39](=[O:40])[NH2:41]

Participants

3

Reactant 2

HCID 220649342-(Piperidin-4-yl)acetamideHCID 444673191-(4-(4-(4-(4-(Aminomethyl)piperidin-1-yl)-5-fluoropyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanone

Product 1

HCID 444671662-(1-(2-(4-(4-Acetylpiperazin-1-yl)phenylamino)-5-fluoropyrimidin-4-yl)piperidin-4-yl)acetamide

Sources & evidence

ORD record
ord-5d8de87da79446589daa07ddccc770f6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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