1,4-Dioxane → 4-(2,4-Dichloro-5-methoxyphenylamino)-7-(5-(morpholinomethyl)pyridin-2-yl)quinoline-3-carbonitrile

HRID 1150087Notes

Reaction equation

HRID 1150087 reaction equation
[CH2:25]([Sn:26]([CH2:27][CH2:28][CH2:29][CH3:43])([c:30]1[cH:31][cH:32][c:33]([CH2:36][N:37]2[CH2:38][CH2:39][O:40][CH2:41][CH2:42]2)[cH:34][n:35]1)[CH2:44][CH2:45][CH2:46][CH3:47])[CH2:48][CH2:49][CH3:50].[CH2:51]1[O:52][CH2:53][CH2:54][O:55][CH2:56]1.[Cl:1][c:2]1[c:3]([NH:4][c:5]2[c:6]([C:16]#[N:17])[cH:7][n:8][c:9]3[cH:10][c:11]([I:15])[cH:12][cH:13][c:14]23)[cH:18][c:19]([O:23][CH3:24])[c:20]([Cl:22])[cH:21]1>>[Cl:1][c:2]1[c:3]([NH:4][c:5]2[c:6]([C:16]#[N:17])[cH:7][n:8][c:9]3[cH:10][c:11](-[c:30]4[cH:31][cH:32][c:33]([CH2:36][N:37]5[CH2:38][CH2:39][O:40][CH2:41][CH2:42]5)[cH:34][n:35]4)[cH:12][cH:13][c:14]23)[cH:18][c:19]([O:23][CH3:24])[c:20]([Cl:22])[cH:21]1

Participants

4

Reactant 3

HCID 312751,4-DioxaneHCID 234379834-(2,4-Dichloro-5-methoxyanilino)-7-iodoquinoline-3-carbonitrileHCID 234381504-[[6-(Tributylstannyl)-3-pyridinyl]methyl]morpholine

Product 1

HCID 234381374-(2,4-Dichloro-5-methoxyphenylamino)-7-(5-(morpholinomethyl)pyridin-2-yl)quinoline-3-carbonitrile

Sources & evidence

ORD record
ord-7a8ff85236a842ee9ecc57ea720c9662
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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