4-[3-(diethylamino)propoxy]Benzenamine → HCID 178418927, compound

HRID 11508Notes

Reaction equation

HRID 11508 reaction equation
[CH2:1]([N:3]([CH2:15][CH3:16])[CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][CH:9]=1)[CH3:2].[Cl:17][C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][CH:26]=1)[NH:23][C:22](=[O:27])[C:21]2=[CH:28]O>>[Cl:17][C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][CH:26]=1)[NH:23][C:22](=[O:27])[C:21]2=[CH:28][NH:14][C:11]1[CH:10]=[CH:9][C:8]([O:7][CH2:6][CH2:5][CH2:4][N:3]([CH2:1][CH3:2])[CH2:15][CH3:16])=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 198634024-[3-(diethylamino)propoxy]BenzenamineHCID 1784190365-chloro-3-(hydroxymethylidene)-1H-indol-2-one

Product 1

HCID 178418927HCID 178418927, compoundYield 46%

Procedure

In a manner similar to that described in Example 231, 4-(3-diethylamino-propoxy)-phenylamine (911 mg, 1.3 equiv.) and 5-chloro-3-hydroxymethylene-1,3-dihydro-indol-2-one (617 mg, 3.16 mmol, 1 equiv.) are reacted to give the named compound as a yellow solid (577 mg, 46%).

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-7168e53720db4e3aa8848f17266be001
Source dataset
uspto-grants-2006_08
Patent number
US07098236B2

Reaction notes

Loading…