1,4-Dioxane → (6-(5-(1,3-Dioxolan-2-yl)-furan-2-yl)-pyrido[3,4-d]pyrimidin-4-yl)-(4-(3-fluorobenzyloxy)-phenyl)-amine

HRID 1150819Notes

Reaction equation

HRID 1150819 reaction equation
[Cl:1][c:2]1[cH:3][c:4]2[c:5]([n:6][cH:7][n:8][c:9]2[NH:10][c:11]2[cH:12][cH:13][c:14]([O:17][CH2:18][c:19]3[cH:20][c:21]([F:25])[cH:22][cH:23][cH:24]3)[cH:15][cH:16]2)[cH:26][n:27]1.[O:28]1[CH:29]([c:33]2[cH:34][cH:35][c:36]([Sn:38]([CH2:39][CH2:40][CH2:41][CH3:42])([CH2:43][CH2:44][CH2:45][CH3:46])[CH2:47][CH2:48][CH2:49][CH3:50])[o:37]2)[O:30][CH2:31][CH2:32]1.[O:51]1[CH2:52][CH2:53][O:54][CH2:55][CH2:56]1>>[c:2]1(-[c:36]2[cH:35][cH:34][c:33]([CH:29]3[O:28][CH2:32][CH2:31][O:30]3)[o:37]2)[cH:3][c:4]2[c:5]([n:6][cH:7][n:8][c:9]2[NH:10][c:11]2[cH:12][cH:13][c:14]([O:17][CH2:18][c:19]3[cH:20][c:21]([F:25])[cH:22][cH:23][cH:24]3)[cH:15][cH:16]2)[cH:26][n:27]1

Participants

4

Reactant 3

HCID 312751,4-DioxaneHCID 10960952Stannane, tributyl[5-(1,3-dioxolan-2-yl)-2-furanyl]-HCID 21952062(6-Chloropyrido[3,4-d]pyrimidin-4-yl)-(4-(3-fluorobenzyloxy)-phenyl)-amine

Product 1

HCID 21952074(6-(5-(1,3-Dioxolan-2-yl)-furan-2-yl)-pyrido[3,4-d]pyrimidin-4-yl)-(4-(3-fluorobenzyloxy)-phenyl)-amine

Sources & evidence

ORD record
ord-b76ef08b896543a59dbddd0059695285
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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