4-[3-(diethylamino)propoxy]Benzenamine → HCID 178419026, compound

HRID 11509Notes

Reaction equation

HRID 11509 reaction equation
[CH2:1]([N:3]([CH2:15][CH3:16])[CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][CH:9]=1)[CH3:2].[F:17][C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][CH:26]=1)[NH:23][C:22](=[O:27])[C:21]2=[CH:28]O>>[CH2:15]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:9]=[CH:10][C:11]([NH:14][CH:28]=[C:21]2[C:20]3[C:24](=[CH:25][CH:26]=[C:18]([F:17])[CH:19]=3)[NH:23][C:22]2=[O:27])=[CH:12][CH:13]=1)[CH3:16]

Participants

3

Reactant 2

HCID 198634024-[3-(diethylamino)propoxy]BenzenamineHCID 178418836HCID 178418836, compound

Product 1

HCID 178419026HCID 178419026, compoundYield 41%

Procedure

In a manner similar to that described in Example 231, 4-(3-diethylamino-propoxy)-phenylamine (161 mg, 1.3 equiv.) and 5-fluoro-3-hydroxymethylene-1,3-dihydro-indol-2-one (100 mg, 0.56 mmol, 1 equiv.) are reacted to give the named compound as a yellow solid (88 mg, 41%).

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-8efe51c5709445b7b864f1173e787e4c
Source dataset
uspto-grants-2006_08
Patent number
US07098236B2

Reaction notes

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