4-[3-(diethylamino)propoxy]Benzenamine → HCID 178419038, compound

HRID 11510Notes

Reaction equation

HRID 11510 reaction equation
[CH2:1]([N:3]([CH2:15][CH3:16])[CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][CH:9]=1)[CH3:2].[F:17][C:18]1[CH:26]=[C:25]2[C:21]([C:22](=[CH:28]O)[C:23](=[O:27])[NH:24]2)=[CH:20][CH:19]=1>>[CH2:15]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:9]=[CH:10][C:11]([NH:14][CH:28]=[C:22]2[C:21]3[C:25](=[CH:26][C:18]([F:17])=[CH:19][CH:20]=3)[NH:24][C:23]2=[O:27])=[CH:12][CH:13]=1)[CH3:16]

Participants

3

Reactant 2

HCID 198634024-[3-(diethylamino)propoxy]BenzenamineHCID 178418700HCID 178418700, compound

Product 1

HCID 178419038HCID 178419038, compoundYield 61.4%

Procedure

In a manner similar to that described in Example 231, 4-(3-diethylamino-propoxy)-phenylamine (5 g, 1.3 equiv.) and 6-fluoro-3-hydroxymethylene-1,3-dihydro-indol-2-one (3.12 g, 17.4 mmol, 1 equiv.) are reacted to give the named compound as a yellow solid (4.1 g, 61%).

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-0b04e4dbf963449c9950d42ba3e15343
Source dataset
uspto-grants-2006_08
Patent number
US07098236B2

Reaction notes

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