Imidazole → 1-(5-Bromo-2-fluorophenyl)-3-(tert-butyldimethylsilyloxy)-2,2-difluoropropan-1-ol

HRID 1151278Notes

Reaction equation

HRID 1151278 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([F:15])[c:6]([CH:8]([C:9]([CH2:10][OH:11])([F:12])[F:13])[OH:14])[cH:7]1.[C:21]([CH3:22])([CH3:23])([CH3:24])[Si:25]([CH3:26])([CH3:27])[Cl:28].[Cl:29][CH2:30][Cl:31].[nH:16]1[cH:17][cH:18][n:19][cH:20]1>>[Br:1][c:2]1[cH:3][cH:4][c:5]([F:15])[c:6]([CH:8]([C:9]([CH2:10][O:11][Si:25]([C:21]([CH3:22])([CH3:23])[CH3:24])([CH3:26])[CH3:27])([F:12])[F:13])[OH:14])[cH:7]1

Participants

5

Reactant 4

HCID 795ImidazoleHCID 6344DichloromethaneHCID 28928tert-Butyldimethylsilyl chlorideHCID 666662611-(5-Bromo-2-fluorophenyl)-2,2-difluoropropane-1,3-diol

Product 1

HCID 666654561-(5-Bromo-2-fluorophenyl)-3-(tert-butyldimethylsilyloxy)-2,2-difluoropropan-1-ol

Sources & evidence

ORD record
ord-6cd875ec47cd428fa0af909823ad6ade
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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