4-[3-(1-Piperidinyl)propoxy]aniline → HCID 178418748, compound

HRID 11513Notes

Reaction equation

HRID 11513 reaction equation
[N:1]1([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[F:18][C:19]1[CH:27]=[C:26]2[C:22]([C:23](=[CH:29]O)[C:24](=[O:28])[NH:25]2)=[CH:21][CH:20]=1>>[F:18][C:19]1[CH:27]=[C:26]2[C:22]([C:23](=[CH:29][NH:17][C:14]3[CH:13]=[CH:12][C:11]([O:10][CH2:9][CH2:8][CH2:7][N:1]4[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]4)=[CH:16][CH:15]=3)[C:24](=[O:28])[NH:25]2)=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 219749324-[3-(1-Piperidinyl)propoxy]anilineHCID 178418700HCID 178418700, compound

Product 1

HCID 178418748HCID 178418748, compoundYield 59%

Procedure

In a manner similar to that described in Example 231, 4-(3-Piperidin-1-yl-propoxy)-phenylamine (0.61 g, 1.3 equiv.) and 6-fluoro-3-hydroxymethylene-1,3-dihydro-indol-2-one (0.358 g, 2.00 mmol, 1 equiv.) are reacted to give the named compound as a yellow solid (465 mg, 59%).

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-39972d6427cf4e2ea1dd90c91ff689a3
Source dataset
uspto-grants-2006_08
Patent number
US07098236B2

Reaction notes

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