3-(2,5-Dichloropyrimidin-4-yl)-1H-indole → 5-Chloro-4-(1H-indol-3-yl)-N-(2-methoxy-5-methyl-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidin-2-amine

HRID 115131Notes

Reaction equation

HRID 115131 reaction equation
[CH3:18][O:19][c:20]1[c:21]([NH2:22])[cH:23][c:24]([CH3:40])[c:25]([N:27]2[CH2:28][CH2:29][CH:30]([N:33]3[CH2:34][CH2:35][N:36]([CH3:39])[CH2:37][CH2:38]3)[CH2:31][CH2:32]2)[cH:26]1.[Cl:1][c:2]1[n:3][cH:4][c:5]([Cl:17])[c:6](-[c:8]2[cH:9][nH:10][c:11]3[cH:12][cH:13][cH:14][cH:15][c:16]23)[n:7]1>>[c:2]1([NH:22][c:21]2[c:20]([O:19][CH3:18])[cH:26][c:25]([N:27]3[CH2:28][CH2:29][CH:30]([N:33]4[CH2:34][CH2:35][N:36]([CH3:39])[CH2:37][CH2:38]4)[CH2:31][CH2:32]3)[c:24]([CH3:40])[cH:23]2)[n:3][cH:4][c:5]([Cl:17])[c:6](-[c:8]2[cH:9][nH:10][c:11]3[cH:12][cH:13][cH:14][cH:15][c:16]23)[n:7]1

Participants

3

Reactant 2

HCID 566553763-(2,5-Dichloropyrimidin-4-yl)-1H-indoleHCID 580714632-Methoxy-5-methyl-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline

Product 1

HCID 580714285-Chloro-4-(1H-indol-3-yl)-N-(2-methoxy-5-methyl-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidin-2-amine

Sources & evidence

ORD record
ord-3ac2c197817c4a02a53d956b774c542a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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