Methanol → Veonetinib

HRID 1151368Notes

Reaction equation

HRID 1151368 reaction equation
[BH4-:36].[CH3:38][OH:39].[F:1][c:2]1[c:3]2[cH:4][c:5]([CH3:35])[nH:6][c:7]2[cH:8][cH:9][c:10]1[O:11][c:12]1[cH:13][cH:14][n:15][c:16]2[cH:17][c:18]([O:24][CH2:25][CH2:26][N:27]3[CH2:28][C:29]4([CH2:30][CH2:31]4)[C:32](=[O:34])[CH2:33]3)[c:19]([O:22][CH3:23])[cH:20][c:21]12.[Na+:37]>>[F:1][c:2]1[c:3]2[cH:4][c:5]([CH3:35])[nH:6][c:7]2[cH:8][cH:9][c:10]1[O:11][c:12]1[cH:13][cH:14][n:15][c:16]2[cH:17][c:18]([O:24][CH2:25][CH2:26][N:27]3[CH2:28][C:29]4([CH2:30][CH2:31]4)[CH:32]([OH:34])[CH2:33]3)[c:19]([O:22][CH3:23])[cH:20][c:21]12

Participants

5

Reactant 4

HCID 887MethanolHCID 923Sodium ionHCID 28123BorohydrideHCID 461764815-(2-(4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)ethyl)-5-azaspiro[2.4]-heptan-7-one

Product 1

HCID 46176482Veonetinib

Sources & evidence

ORD record
ord-a503fa9d757441b3aec6acf7ced36e61
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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