2-Bromo-5-(trifluoromethyl)benzyl alcohol → (2'-Hydroxymethyl-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester

HRID 1151436Notes

Reaction equation

HRID 1151436 reaction equation
[Br:23][c:24]1[c:25]([CH2:26][OH:27])[cH:28][c:29]([C:32]([F:33])([F:34])[F:35])[cH:30][cH:31]1.[CH3:1][O:2][C:3]([CH2:4][c:5]1[cH:6][c:7]([B:13]2[O:14][C:15]([CH3:16])([CH3:17])[C:18]([CH3:19])([CH3:20])[O:21]2)[c:8]([O:11][CH3:12])[cH:9][cH:10]1)=[O:22]>>[CH3:1][O:2][C:3]([CH2:4][c:5]1[cH:6][c:7](-[c:24]2[c:25]([CH2:26][OH:27])[cH:28][c:29]([C:32]([F:33])([F:34])[F:35])[cH:30][cH:31]2)[c:8]([O:11][CH3:12])[cH:9][cH:10]1)=[O:22]

Participants

3

Reactant 2

HCID 27562482-Bromo-5-(trifluoromethyl)benzyl alcoholHCID 57576289Methyl 2-(4-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)phenyl)acetate

Product 1

HCID 66606415(2'-Hydroxymethyl-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester

Sources & evidence

ORD record
ord-4d540e7f97544de4bc171bb24161eb9e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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