4-(4-Piperidin-1-yl-butoxy)-phenylamine → HCID 178418890, compound

HRID 11516Notes

Reaction equation

HRID 11516 reaction equation
[N:1]1([CH2:7][CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][C:15]([NH2:18])=[CH:14][CH:13]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:19][C:20]1[CH:28]=[CH:27][CH:26]=[C:25]2[C:21]=1[C:22](=[CH:30]O)[C:23](=[O:29])[NH:24]2>>[CH3:19][C:20]1[CH:28]=[CH:27][CH:26]=[C:25]2[C:21]=1[C:22](=[CH:30][NH:18][C:15]1[CH:14]=[CH:13][C:12]([O:11][CH2:10][CH2:9][CH2:8][CH2:7][N:1]3[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]3)=[CH:17][CH:16]=1)[C:23](=[O:29])[NH:24]2

Participants

3

Reactant 2

HCID 219752304-(4-Piperidin-1-yl-butoxy)-phenylamineHCID 178418763HCID 178418763, compound

Product 1

HCID 178418890HCID 178418890, compoundYield 53.2%

Procedure

In a manner similar to that described in Example 231, 4-(4-Piperidin-1-yl-butoxy)-phenylamine (1.19 g, 1.1 equiv.) and 4-methyl-3-hydroxymethylene-1,3-dihydro-indol-2-one (0.79 g, 4.5 mmol, 1 equiv.) are reacted to give the named compound as a yellow solid (0.97 g, 53%).

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-85af3b0df0924a6f8cf6ee4342847a42
Source dataset
uspto-grants-2006_08
Patent number
US07098236B2

Reaction notes

Loading…