4-(4-Piperidin-1-yl-butoxy)-phenylamine → HCID 178418885, compound

HRID 11517Notes

Reaction equation

HRID 11517 reaction equation
[N:1]1([CH2:7][CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][C:15]([NH2:18])=[CH:14][CH:13]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[F:19][C:20]1[CH:28]=[C:27]2[C:23]([C:24](=[CH:30]O)[C:25](=[O:29])[NH:26]2)=[CH:22][CH:21]=1>>[F:19][C:20]1[CH:28]=[C:27]2[C:23]([C:24](=[CH:30][NH:18][C:15]3[CH:14]=[CH:13][C:12]([O:11][CH2:10][CH2:9][CH2:8][CH2:7][N:1]4[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]4)=[CH:17][CH:16]=3)[C:25](=[O:29])[NH:26]2)=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 219752304-(4-Piperidin-1-yl-butoxy)-phenylamineHCID 178418700HCID 178418700, compound

Product 1

HCID 178418885HCID 178418885, compoundYield 73%

Procedure

In a manner similar to that described in Example 231, 4-(4-piperidin-1-yl-butoxy)-phenylamine (400 mg, 1.1 equiv.) and 6-fluoro-3-hydroxymethylene-1,3-dihydro-indol-2-one (263 mg, 1.47 mmol, 1 equiv.) are reacted to give the named compound as a yellow solid (435 mg, 73%).

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-bd36ddb1ba5c4fc28ef4bc92558c279d
Source dataset
uspto-grants-2006_08
Patent number
US07098236B2

Reaction notes

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