4-(3-(Diethylamino)propoxy)-3-fluoroaniline → HCID 178418913, compound

HRID 11520Notes

Reaction equation

HRID 11520 reaction equation
[CH2:1]([N:3]([CH2:16][CH3:17])[CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][C:9]=1[F:15])[CH3:2].[CH3:18][C:19]1[CH:27]=[CH:26][CH:25]=[C:24]2[C:20]=1[C:21](=[CH:29]O)[C:22](=[O:28])[NH:23]2>>[CH2:16]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([NH:14][CH:29]=[C:21]2[C:20]3[C:24](=[CH:25][CH:26]=[CH:27][C:19]=3[CH3:18])[NH:23][C:22]2=[O:28])=[CH:10][C:9]=1[F:15])[CH3:17]

Participants

3

Reactant 2

HCID 219747414-(3-(Diethylamino)propoxy)-3-fluoroanilineHCID 178418763HCID 178418763, compound

Product 1

HCID 178418913HCID 178418913, compoundYield 49.3%

Procedure

In a manner similar to that described in Example 231, 4-(3-diethylamino-propoxy)-3-fluoro-phenylamine (400 mg, 1.1 equiv.) and 4-methyl-3-hydroxymethylene-1,3-dihydro-indol-2-one (263 mg, 1.5 mmol, 1 equiv.) are reacted to give the named compound as a yellow solid (294 mg, 49%).

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-978f02367a434d51be57306a9935f100
Source dataset
uspto-grants-2006_08
Patent number
US07098236B2

Reaction notes

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