4-(3-(Diethylamino)propoxy)-3-fluoroaniline → HCID 178418709, compound

HRID 11521Notes

Reaction equation

HRID 11521 reaction equation
[CH2:1]([N:3]([CH2:16][CH3:17])[CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][C:9]=1[F:15])[CH3:2].[F:18][C:19]1[CH:27]=[C:26]2[C:22]([C:23](=[CH:29]O)[C:24](=[O:28])[NH:25]2)=[CH:21][CH:20]=1>>[CH2:16]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([NH:14][CH:29]=[C:23]2[C:22]3[C:26](=[CH:27][C:19]([F:18])=[CH:20][CH:21]=3)[NH:25][C:24]2=[O:28])=[CH:10][C:9]=1[F:15])[CH3:17]

Participants

3

Reactant 2

HCID 219747414-(3-(Diethylamino)propoxy)-3-fluoroanilineHCID 178418700HCID 178418700, compound

Product 1

HCID 178418709HCID 178418709, compoundYield 32.4%

Procedure

In a manner similar to that described in Example 231, 4-(3-diethylamino-propoxy)-3-fluoro-phenylamine (400 mg, 1.1 equiv.) and 6-fluoro-3-hydroxymethylene-1,3-dihydro-indol-2-one (269 mg, 1.5 mmol, 1 equiv.) are reacted to give the named compound as a yellow solid (195 mg, 32%).

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-13194c9eb6f14dfab646843313ca3dbe
Source dataset
uspto-grants-2006_08
Patent number
US07098236B2

Reaction notes

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