4-(2-Piperidin-1-yl-ethoxy)-phenylamine → HCID 178419027, compound

HRID 11526Notes

Reaction equation

HRID 11526 reaction equation
[N:1]1([CH2:7][CH2:8][O:9][C:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[F:17][C:18]1[CH:26]=[C:25]2[C:21]([C:22](=[CH:28]O)[C:23](=[O:27])[NH:24]2)=[CH:20][CH:19]=1>>[F:17][C:18]1[CH:26]=[C:25]2[C:21]([C:22](=[CH:28][NH:16][C:13]3[CH:12]=[CH:11][C:10]([O:9][CH2:8][CH2:7][N:1]4[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]4)=[CH:15][CH:14]=3)[C:23](=[O:27])[NH:24]2)=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 30160254-(2-Piperidin-1-yl-ethoxy)-phenylamineHCID 178418700HCID 178418700, compound

Product 1

HCID 178419027HCID 178419027, compoundYield 70%

Procedure

In a manner similar to that described in Example 231, 4-(2-piperidin-1-yl-ethoxy)-phenylamine (737 mg, 1.2 equiv.) and 6-fluoro-3-hydroxymethylene-1,3-dihydro-indol-2-one (500 mg, 2.79 mmol, 1 equiv.) are reacted to give the named compound as a yellow solid (745 mg, 70%).

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-2c1dfd4b31064722a1df6681b995593f
Source dataset
uspto-grants-2006_08
Patent number
US07098236B2

Reaction notes

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