4-(2-Piperidin-1-yl-ethoxy)-phenylamine → HCID 178418766, compound

HRID 11527Notes

Reaction equation

HRID 11527 reaction equation
[N:1]1([CH2:7][CH2:8][O:9][C:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.O[CH:18]=[C:19]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[NH:21][C:20]1=[O:28]>>[N:1]1([CH2:7][CH2:8][O:9][C:10]2[CH:11]=[CH:12][C:13]([NH:16][CH:18]=[C:19]3[C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[NH:21][C:20]3=[O:28])=[CH:14][CH:15]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 30160254-(2-Piperidin-1-yl-ethoxy)-phenylamineHCID 1784187413-(hydroxymethylidene)-1H-indol-2-one

Product 1

HCID 178418766HCID 178418766, compoundYield 80%

Procedure

In a manner similar to that described in Example 231, 4-(2-piperidin-1-yl-ethoxy)-phenylamine (820 mg, 1.2 equiv.) and 3-hydroxymethylene-1,3-dihydro-indol-2-one (500 mg, 3.11 mmol, 1 equiv.) are reacted to give the named compound as a yellow solid (899 mg, 80%).

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-09bf3815c8364dcdaaccc405ae35d62c
Source dataset
uspto-grants-2006_08
Patent number
US07098236B2

Reaction notes

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