4-[3-(1-Piperidinyl)propoxy]aniline → HCID 178418941, compound

HRID 11528Notes

Reaction equation

HRID 11528 reaction equation
[N:1]1([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[F:18][C:19]1[CH:27]=[CH:26][CH:25]=[C:24]2[C:20]=1[C:21](=[CH:29]O)[C:22](=[O:28])[NH:23]2>>[F:18][C:19]1[CH:27]=[CH:26][CH:25]=[C:24]2[C:20]=1[C:21](=[CH:29][NH:17][C:14]1[CH:13]=[CH:12][C:11]([O:10][CH2:9][CH2:8][CH2:7][N:1]3[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]3)=[CH:16][CH:15]=1)[C:22](=[O:28])[NH:23]2

Participants

3

Reactant 2

HCID 219749324-[3-(1-Piperidinyl)propoxy]anilineHCID 178418878HCID 178418878, compound

Product 1

HCID 178418941HCID 178418941, compound

Procedure

In a manner similar to that described in Example 231, 4-(3-piperidin-1-yl-propoxy)-phenylamine (610 mg, 1.3 equiv.) and 4-fluoro-3-hydroxymethylene-1,3-dihydro-indol-2-one (360 mg, 2 mmol, 1 equiv.) are converted to the named compound as a yellow solid (625 mg, 79%).

Sources & evidence

ORD record
ord-4ae606b410724582ab5bb8053290d27b
Source dataset
uspto-grants-2006_08
Patent number
US07098236B2

Reaction notes

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