[4-(4-Amino-phenylcarbamoyl)-benzyl]-carbamic acid tert-butyl ester → {4-[4-(5-Biphenyl-4-yl-pyrazolo[1,5-c]pyrimidin-7-ylamino)-phenylcarbamoyl]benzyl}-carbamic acid tert-butyl ester

HRID 115283Notes

Reaction equation

HRID 115283 reaction equation
[C:26]([CH3:27])([CH3:28])([CH3:29])[O:30][C:31]([NH:32][CH2:33][c:34]1[cH:35][cH:36][c:37]([C:40]([NH:41][c:42]2[cH:43][cH:44][c:45]([NH2:48])[cH:46][cH:47]2)=[O:49])[cH:38][cH:39]1)=[O:50].[c:1]1(-[c:20]2[cH:21][cH:22][cH:23][cH:24][cH:25]2)[cH:2][cH:3][c:4](-[c:7]2[cH:8][c:9]3[n:10]([c:11]([S:13]([CH3:14])(=[O:15])=[O:16])[n:12]2)[n:17][cH:18][cH:19]3)[cH:5][cH:6]1>>[c:1]1(-[c:20]2[cH:21][cH:22][cH:23][cH:24][cH:25]2)[cH:2][cH:3][c:4](-[c:7]2[cH:8][c:9]3[n:10]([c:11]([NH:48][c:45]4[cH:44][cH:43][c:42]([NH:41][C:40]([c:37]5[cH:36][cH:35][c:34]([CH2:33][NH:32][C:31]([O:30][C:26]([CH3:27])([CH3:28])[CH3:29])=[O:50])[cH:39][cH:38]5)=[O:49])[cH:47][cH:46]4)[n:12]2)[n:17][cH:18][cH:19]3)[cH:5][cH:6]1

Participants

3

Reactant 2

HCID 67319189[4-(4-Amino-phenylcarbamoyl)-benzyl]-carbamic acid tert-butyl esterHCID 673194015-Biphenyl-4-yl-7-methanesulfonyl-pyrazolo[1,5-c]pyrimidine

Product 1

HCID 67319580{4-[4-(5-Biphenyl-4-yl-pyrazolo[1,5-c]pyrimidin-7-ylamino)-phenylcarbamoyl]benzyl}-carbamic acid tert-butyl ester

Sources & evidence

ORD record
ord-2cbb888e880f4e3dad9cd4f652c8e0b2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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