4-(2-Piperidin-1-yl-ethoxy)-phenylamine → HCID 178418818, compound

HRID 11529Notes

Reaction equation

HRID 11529 reaction equation
[N:1]1([CH2:7][CH2:8][O:9][C:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[F:17][C:18]1[CH:26]=[CH:25][CH:24]=[C:23]2[C:19]=1[C:20](=[CH:28]O)[C:21](=[O:27])[NH:22]2>>[F:17][C:18]1[CH:26]=[CH:25][CH:24]=[C:23]2[C:19]=1[C:20](=[CH:28][NH:16][C:13]1[CH:12]=[CH:11][C:10]([O:9][CH2:8][CH2:7][N:1]3[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]3)=[CH:15][CH:14]=1)[C:21](=[O:27])[NH:22]2

Participants

3

Reactant 2

HCID 30160254-(2-Piperidin-1-yl-ethoxy)-phenylamineHCID 178418878HCID 178418878, compound

Product 1

HCID 178418818HCID 178418818, compoundYield 63%

Procedure

In a manner similar to that described in Example 231, 4-(2-piperidin-1-yl-ethoxy)-phenylamine (600 mg, 1.2 equiv.) and 4-fluoro-3-hydroxymethylene-1,3-dihydro-indol-2-one (407 mg, 2.27 mmol, 1 equiv.) (4-Fluorooxindole may be prepared as described in Synthesis 1991, 10, 871) are reacted to give the named compound as a yellow solid (542 mg, 63%).

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-e18d183b19cc496388abf111c69b9c47
Source dataset
uspto-grants-2006_08
Patent number
US07098236B2

Reaction notes

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