Methanol → Ethyl 2-(4-amino-3-(cyclopropylmethoxy)phenyl)-3-cyclopropylpropanoate

HRID 1152990Notes

Reaction equation

HRID 1152990 reaction equation
[CH3:25][OH:26].[CH:1]1([CH2:4][CH:5]([C:6](=[O:7])[O:8][CH2:9][CH3:10])[c:11]2[cH:12][c:13]([O:20][CH2:21][CH:22]3[CH2:23][CH2:24]3)[c:14]([N+:17]([O-:18])=[O:19])[cH:15][cH:16]2)[CH2:2][CH2:3]1.[OH-:27].[OH-:28].[Pd+2:29]>>[CH:1]1([CH2:4][CH:5]([C:6](=[O:7])[O:8][CH2:9][CH3:10])[c:11]2[cH:12][c:13]([O:20][CH2:21][CH:22]3[CH2:23][CH2:24]3)[c:14]([NH2:17])[cH:15][cH:16]2)[CH2:2][CH2:3]1

Participants

5

Reactant 4

HCID 887MethanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 57995591Ethyl 3-cyclopropyl-2-(3(cyclopropylmethoxy)-4-nitrophenyl)propanoate

Product 1

HCID 57995649Ethyl 2-(4-amino-3-(cyclopropylmethoxy)phenyl)-3-cyclopropylpropanoate

Sources & evidence

ORD record
ord-64554fc627274b7496d7e3c6599ecd37
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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