3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethoxy)-5-[(2-methylcarbamoyl-ethoxyimino)-methyl]-benzamide → 2-(4-ethynyl-2-fluoroanilino)-3,4-difluoro-N-(2-hydroxyethoxy)-5-[[3-(methylamino)-3-oxopropoxy]iminomethyl]benzamide
Reaction equation
[C:34](#[CH:35])[c:36]1[cH:37][cH:38][c:39]([NH:40][c:41]2[c:42]([F:43])[c:44]([F:45])[c:46]([CH:47]=[N:48][O:49][CH2:50][CH2:51][OH:52])[cH:53][c:54]2[C:55]([NH:56][O:57][CH2:58][CH2:59][OH:60])=[O:61])[c:62]([F:63])[cH:64]1.[C:65]([c:66]1[cH:67][cH:68][c:69]([NH:70][c:71]2[c:72]([F:73])[c:74]([F:75])[c:76]([CH:77]=[N:78][O:79][CH2:80][CH2:81][OH:82])[cH:83][c:84]2[C:85]([NH:86][O:87][CH2:88][CH2:89][OH:90])=[O:91])[c:92]([F:93])[cH:94]1)#[CH:95].[F:1][c:2]1[c:3]([NH:25][c:26]2[c:27]([F:33])[cH:28][c:29]([I:32])[cH:30][cH:31]2)[c:4]([C:5](=[O:6])[NH:7][O:8][CH2:9][CH2:10][OH:11])[cH:12][c:13]([CH:16]=[N:17][O:18][CH2:19][CH2:20][C:21]([NH:22][CH3:23])=[O:24])[c:14]1[F:15]>>[F:1][c:2]1[c:3]([NH:25][c:26]2[c:27]([F:33])[cH:28][c:29]([C:34]#[CH:35])[cH:30][cH:31]2)[c:4]([C:5](=[O:6])[NH:7][O:8][CH2:9][CH2:10][OH:11])[cH:12][c:13]([CH:16]=[N:17][O:18][CH2:19][CH2:20][C:21]([NH:22][CH3:23])=[O:24])[c:14]1[F:15]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-0b61a79ced1c464380c3ff5a8f29bcd6
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (7/10)
Reaction notes
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