2,6-Difluorobenzyl alcohol → 4-O-tert-butyl 1-O-[(2,6-difluorophenyl)methyl] 2,6-dimethylpiperazine-1,4-dicarboxylate

HRID 1153552Notes

Reaction equation

HRID 1153552 reaction equation
[Cl:1][C:2](=[O:3])[N:4]1[CH:5]([CH3:18])[CH2:6][N:7]([C:11](=[O:12])[O:13][C:14]([CH3:15])([CH3:16])[CH3:17])[CH2:8][CH:9]1[CH3:10].[F:19][c:20]1[c:21]([CH2:22][OH:23])[c:24]([F:28])[cH:25][cH:26][cH:27]1>>[C:2](=[O:3])([N:4]1[CH:5]([CH3:18])[CH2:6][N:7]([C:11](=[O:12])[O:13][C:14]([CH3:15])([CH3:16])[CH3:17])[CH2:8][CH:9]1[CH3:10])[O:23][CH2:22][c:21]1[c:20]([F:19])[cH:27][cH:26][cH:25][c:24]1[F:28]

Participants

3

Reactant 2

HCID 879212,6-Difluorobenzyl alcoholHCID 22219933rac-tert-butyl (3R,5S)-4-(carboxy)-3,5-dimethylpiperazine-1-carboxylate

Product 1

HCID 222198814-O-tert-butyl 1-O-[(2,6-difluorophenyl)methyl] 2,6-dimethylpiperazine-1,4-dicarboxylate

Sources & evidence

ORD record
ord-e0bf6b71938a48cfa3cb532e74d95038
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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