HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chlorothiazole → 6-fluoro-5H-thiazolo[2,3-b]quinazolin-5-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chlorothiazole | HCID 76429 | — |
| Reactant | Methyl 2-amino-6-fluorobenzoate | HCID 2818492 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 6-fluoro-5H-thiazolo[2,3-b]quinazolin-5-one | HCID 13217001 | — |
Reaction Steps
25.4 parts of methyl 6-fluoroanthranilate and 18 parts of 2-chlorothiazole were heated to 150° C., and the methanol formed was distilled off over a bridge. The reaction was complete after 2 hours. The solid residue was neutralized, and recrystallized from isopropanol. 30 parts of 6-fluoro-5H-thiazolo[2,3-b]quinazolin-5-one of melting point 205°-207° C. were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04486221 |
| Source dataset | uspto-grants-1984_12 |
| ORD ID | ord-106e76b829664d999c76ee99eaeca684 |
| Source note | uspto-grants-1984_12 |