反应详情

A solution of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine (2 gm, 8 mM) and acetic anhydride (10 mls) in acetic acid (20 mls) was stirred and heated to reflux for 2 hours. The solution was then cooled and evaporated down in vacuo. The residue was treated with aqueous 0.880 ammonia (100 mls) and the resultant mixture was stirred for 2 hours. The solid was separated by filtration, dried then recrystallized from isopropanol to give 5-acetamido-3-amino-6-(2,3-dichlorophenyl)-1,2,4-triazine. Yield 1.0 gms (42%), m.p. 250°-252° C. (uncorrected).

1. temperatureheated
2. temperatureto reflux for 2 hours
3. temperatureThe solution was then cooled
4. customevaporated down in vacuo
5. additionThe residue was treated with aqueous 0.880 ammonia (100 mls)
6. customThe solid was separated by filtration
7. customdried
8. customthen recrystallized from isopropanol