Aminoacetamidine Dihydrobromide → 2-Amino-7-butyl-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine

HRID 1153749Notes

Reaction equation

[CH2:1]([N:5]1[CH2:11][CH2:10][C:9](O[Si](C)(C)C)=[C:8](O[Si](C)(C)C)[CH2:7][CH2:6]1)[CH2:2][CH2:3][CH3:4].Br.Br.[NH2:24][CH2:25][C:26]([NH2:28])=[NH:27]>>[NH2:28][C:26]1[CH:25]=[N:24][C:9]2[CH2:10][CH2:11][N:5]([CH2:1][CH2:2][CH2:3][CH3:4])[CH2:6][CH2:7][C:8]=2[N:27]=1

Participants

Reactant 2

HCID 16211382Aminoacetamidine Dihydrobromide

HCID 20436458HCID 20436458, compound

Product 1

HCID 130370362-Amino-7-butyl-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine

Procedure

This compound was prepared analogous to Example 3 from 1-butyl-2,3,6,7-tetrahydro-4,5-bis(trimethylsilyloxy)azepine and 2-amino-acetamidine dihydrobromide.

Sources & evidence

ORD record: ord-15beacc7d78f4fde878f425415270012
Source dataset: uspto-grants-1984_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04486433

Reaction notes

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