Aminoacetamidine Dihydrobromide → 2-Amino-7-acetyl-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine

HRID 1153753Notes

Reaction equation

[C:1]([N:4]1[CH2:10][CH2:9][CH2:8][C:7](=O)[C:6](=O)[CH2:5]1)(=[O:3])[CH3:2].Br.Br.[NH2:15][CH2:16][C:17]([NH2:19])=[NH:18]>>[NH2:19][C:17]1[CH:16]=[N:15][C:8]2[CH2:9][CH2:10][N:4]([C:1](=[O:3])[CH3:2])[CH2:5][CH2:6][C:7]=2[N:18]=1

Participants

Reactant 2

HCID 16211382Aminoacetamidine Dihydrobromide

HCID 204364421-Acetyl-hexahydroazepine-3,4-dione

Product 1

HCID 130370432-Amino-7-acetyl-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine

Procedure

This compound was prepared analogous to Example 13 by reacting a mixture of 1-acetyl-hexhydroazepine-4,5-dione and 1-acetyl-hexahydroazepine-3,4-dione (prepared from 1-acetyl-hexhydroazepine-4-ones by selenium dioxide oxidation in dioxane/water) with 2-amino-acetamidine dihydrobromide.

Workup

customThis compound was prepared analogous to Example 13

Sources & evidence

ORD record: ord-984b5a48a18f4bc5885101bba0f8a79b
Source dataset: uspto-grants-1984_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04486433

Reaction notes

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