Aminoacetamidine Dihydrobromide → ethyl 2-amino-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine-7-carboxylate

HRID 1153754Notes

Reaction equation

HRID 1153754 reaction equation
[N:1]1([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH2:7][CH2:6][CH2:5][C:4](=O)[C:3](=O)[CH2:2]1.N1(C(OCC)=O)CCC(=O)C(=O)CC1.Br.Br.[NH2:31][CH2:32][C:33]([NH2:35])=[NH:34]>>[NH2:35][C:33]1[CH:32]=[N:31][C:5]2[CH2:6][CH2:7][N:1]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH2:2][CH2:3][C:4]=2[N:34]=1

Participants

4

Reactant 3

HCID 16211382Aminoacetamidine DihydrobromideHCID 20436398Ethyl hexahydroazepine-3,4-dione-1-carboxylateHCID 20436412Ethyl hexahydroazepine-4,5-dione-1-carboxylate

Product 1

HCID 13037044ethyl 2-amino-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine-7-carboxylate

Procedure

This compound was prepared analogous to Example 13 by reacting a mixture of ethyl hexahydroazepine-3,4-dione-1-carboxylate and ethyl hexahydroazepine-4,5-dione-1-carboxylate (prepared from ethyl hexahydroazepine-4-one-1-carboxylate by selenium dioxide oxidation) with 2-amino-acetamidine dihydrobromide.

Workup

  1. customThis compound was prepared analogous to Example 13

Sources & evidence

ORD record
ord-e35d22aa055a4a4fb1baff867ad8af10
Source dataset
uspto-grants-1984_12
Patent number
US04486433

Reaction notes

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