反应详情

温度

180 °C

A mixture of 1.6 gm (5.2 mmols) of diethyl 2-amino-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine-3,7-dicarboxylate and 20 ml of 80% sulfuric acid was heated for 30 minutes at 180° C. Thereafter, the mixture was cooled, made alkaline with an aqueous sodium carbonate solution, and extracted with chloroform for 24 hours with a perforator. The chloroform extract was chromatographed in silicagel with chloroform/methanol/concentrated ammonia (24:12:1) as the mobile phase.

1. temperatureThereafter, the mixture was cooled
2. extractionextracted with chloroform for 24 hours with a perforator
3. extractionThe chloroform extract
4. customwas chromatographed in silicagel with chloroform/methanol/concentrated ammonia (24:12:1) as the mobile phase