HCID 54083585, compound → HCID 131713974, compound

HRID 1153777Notes

Reaction equation

HRID 1153777 reaction equation
[Cl:1][CH2:2][C:3]([NH:5][C:6]1[S:7][CH:8]=[C:9]([C:11](=[N:15][O:16][CH2:17][CH3:18])[C:12]([OH:14])=O)[N:10]=1)=[O:4].[NH2:19][CH:20]1[C:46](=[O:47])[N:22]2[C:23]([C:30]([O:32][CH:33]([C:40]3[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=3)[C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)=[O:31])=[C:24]([CH2:27][O:28][CH3:29])[CH2:25][S:26][C@H:21]12>>[Cl:1][CH2:2][C:3]([NH:5][C:6]1[S:7][CH:8]=[C:9]([C:11](=[N:15][O:16][CH2:17][CH3:18])[C:12]([NH:19][CH:20]2[C:46](=[O:47])[N:22]3[C:23]([C:30]([O:32][CH:33]([C:40]4[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=4)[C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=4)=[O:31])=[C:24]([CH2:27][O:28][CH3:29])[CH2:25][S:26][C@H:21]23)=[O:14])[N:10]=1)=[O:4]

Participants

3

Reactant 2

HCID 54083585HCID 54083585, compoundHCID 70432979HCID 70432979, compound

Product 1

HCID 131713974HCID 131713974, compoundYield 84%

Procedure

Following the method of Preparation 3, 225 mg of 2-(2-chloroacetamidothiazol-4-yl)-2-ethoxyiminoacetic acid and 200 mg of benzhydryl 7-amino-3-methoxymethyl-3-cephem-4-carboxylate were reacted to give 280 mg of benzhydryl 7-[2-(2-chloroacetamidothiazol-4-yl)-2-ethoxyiminoacetamido]-3-methoxymethyl-3-cephem-4-carboxylate, in the form of a yellow powder.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-5a179ccfa1a34759a38d8f744ec57fb6
Source dataset
uspto-grants-1984_12
Patent number
US04486425

Reaction notes

Loading…