HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Acetamidothiazole → 2-[(2-chloro-1-oxo-propyl)-amino]-beta-oxo-N-(2-thiazolyl)-3-fluoro-benzene propanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Acetamidothiazole | HCID 17625 | — |
| Reactant | 2-(1-Chloroethyl)-8-fluoro-4H-3,1-benzoxazin-4-one | HCID 20145691 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | HCID 178418244 | HCID 178418244 | — |
| Product | 2-[(2-chloro-1-oxo-propyl)-amino]-beta-oxo-N-(2-thiazolyl)-3-fluoro-benzene propanamide | HCID 13423086 | 39.2% |
Reaction Steps
Using the procedure of Step A of Example 6, a solution of 17 g of N-(2-thiazolyl)-acetamide in 340 ml of tetrahydrofuran, 160 ml of butyllithium-hexane solution and 0.06 moles of the product of step D in 130 ml of tetrahydrofuran were reacted to obtain 8.7 g of 2-[(2-chloro-1-oxo-propyl)amino]-β-oxo-N-(2-thiazolyl)-3-fluoro-benzene propanamide melting towards 170° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04486438 |
| Source dataset | uspto-grants-1984_12 |
| ORD ID | ord-a0476d5e688d49be885c92cf013e434e |
| Source note | uspto-grants-1984_12 |