HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Acetamidothiazole → 2-[(2-chloro-1-oxo-butyl)-amino]-beta-oxo-N-(2-thiazolyl)-3-trifloromethyl-benzenepropanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Acetamidothiazole | HCID 17625 | — |
| Reactant | 4H-3,1-Benzoxazin-4-one, 2-(1-chloropropyl)-8-(trifluoromethyl)- | HCID 13423081 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | 2-[(2-chloro-1-oxo-butyl)-amino]-beta-oxo-N-(2-thiazolyl)-3-trifloromethyl-benzenepropanamide | HCID 13423084 | 21.7% |
Reaction Steps
Using the procedure of Step A of Example 6, a solution of 16.58 g of N-(2-thiazolyl)-acetamide in 340 ml of tetrahydrofuran, 155 ml of a solution of butyllithium in hexane and a solution of 17 g of the product of Step A in 170 ml of tetrahydrofuran were reacted to obtain 5.5 g of 2-[(2-chloro-1-oxo-butyl)-amino]-β-oxo-N-(2-thiazolyl)-3-trifluoromethyl-benzenepropanamide melting at 170° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04486438 |
| Source dataset | uspto-grants-1984_12 |
| ORD ID | ord-f63dad8cddb9493b91b1a7cc7e825b67 |
| Source note | uspto-grants-1984_12 |