HCID 20436796, compound → HCID 20436827, compound

HRID 1153822Notes

Reaction equation

HRID 1153822 reaction equation
C([O:3][C:4]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH:12]1[N:16]([CH2:17][CH2:18][CH:19]([O:25][CH:26]2[CH2:31][CH2:30][CH2:29][CH2:28][O:27]2)[CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[C:15](=[O:32])[NH:14][C:13]1=[O:33])=[O:5])C>[OH-].[Na+]>[C:4]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH:12]1[N:16]([CH2:17][CH2:18][CH:19]([O:25][CH:26]2[CH2:31][CH2:30][CH2:29][CH2:28][O:27]2)[CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[C:15](=[O:32])[NH:14][C:13]1=[O:33])([OH:5])=[O:3]

Participants

3

Reactant 1

HCID 20436796HCID 20436796, compound

Product 1

HCID 20436827HCID 20436827, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

A solution of the ester (6.2 g) in 0.5N-sodium hydroxide solution (80 ml) was allowed to stand at room temperature for 21/2 hours after which the solution was washed with ether, the aqueous layer was acidified with 2N-hydrochloric acid, and the precipitated oil was extracted with ether. The washed and dried ether extract was evaporated to give 5-(6-carboxyhexyl)-1-(3-(tetrahydropyran-2-yloxy)octyl)hydantoin as a yellow oil.

Workup

  1. customto stand at room temperature for 21
  2. custom2 hours
  3. washwas washed with ether
  4. extractionthe precipitated oil was extracted with ether
  5. washThe washed
  6. extractiondried ether extract
  7. customwas evaporated

Sources & evidence

ORD record
ord-bbf745a212fc4aae870cbd4bc20112d3
Source dataset
uspto-grants-1984_12
Patent number
US04486443

Reaction notes

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