Acetamidomalonic acid diethyl ester → Diethyl acetamido-(6-methoxycarbonylhex-2-ynyl)malonate

HRID 1153828Notes

Reaction equation

HRID 1153828 reaction equation
[C:1]([NH:4][CH:5]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:6]([O:8][CH2:9][CH3:10])=[O:7])(=[O:3])[CH3:2].Br[CH2:17][C:18]#[C:19][CH2:20][CH2:21][CH2:22][C:23]([O:25][CH3:26])=[O:24]>>[C:1]([NH:4][C:5]([CH2:17][C:18]#[C:19][CH2:20][CH2:21][CH2:22][C:23]([O:25][CH3:26])=[O:24])([C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:6]([O:8][CH2:9][CH3:10])=[O:7])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 14041Acetamidomalonic acid diethyl esterHCID 11287432Methyl 7-bromohept-5-ynoate

Product 1

HCID 54058519Diethyl acetamido-(6-methoxycarbonylhex-2-ynyl)malonate

Procedure

Under the reaction conditions described in Example 1A diethyl acetamidomalonate and methyl 7-bromohept-5-ynoate reacted to give diethyl acetamido-(6-methoxycarbonylhex-2-ynyl)malonate as a yellow oil.

Workup

  1. customUnder the reaction conditions
  2. customreacted

Sources & evidence

ORD record
ord-7696abfd8704428f9b37e9ce8ebb0c3a
Source dataset
uspto-grants-1984_12
Patent number
US04486443

Reaction notes

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