Hydrochloric Acid → HCID 13369445, compound

Participants

Reaction Steps

To 30 ml of dry methylene chloride was added 7.5 ml of 2M trimethylaluminum in toluene under a nitrogen atmosphere. Subsequently, 2.0 g of cyclopentanol in 2 ml methylene chloride was added via syringe and the mixture stirred at ambient temperature for 15 minutes. After addition of 2.0 g of methyl 2-{[(4,6-dimethylfuro[2,3-d]pyrimidin-2-yl)aminocarbonyl]aminosulfonyl}benzoate to the mixture, the reaction was heated to reflux for 48 hours. The mixture was then cooled and poured into excess dilute hydrochloric acid and mixed with ethyl acetate.

Provenance & Evidence