Bromine → 1-Bromo-5-chloro-1-(4-chlorophenoxy)-3,3-dimethylpentan-2-one

HRID 1153950Notes

Reaction equation

HRID 1153950 reaction equation
[Cl:1][C:2]1[CH:17]=[CH:16][C:5]([O:6][CH2:7][C:8](=[O:15])[C:9]([CH3:14])([CH3:13])[CH2:10][CH2:11][Cl:12])=[CH:4][CH:3]=1.[Br:18]Br>C(Cl)Cl>[Br:18][CH:7]([O:6][C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:17][CH:16]=1)[C:8](=[O:15])[C:9]([CH3:13])([CH3:14])[CH2:10][CH2:11][Cl:12]

Participants

4

Reactant 2

HCID 24408BromineHCID 132542805-Chloro-1-(4-chlorophenoxy)-3,3-dimethylpentan-2-one

Product 1

HCID 132542811-Bromo-5-chloro-1-(4-chlorophenoxy)-3,3-dimethylpentan-2-one

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

136 g (0.5 mol) of 1-(4-chlorophenoxy)-5-chloro-3,3-dimethyl-pentan-2-one are dissolved in 1,000 ml of methylene chloride. 79.9 g (1 mol) of bromine are added dropwise, at room temperature, in such a manner that the solution is constantly decolourised. Thereafter, stirring is continued for 1 hour at room temperature, and the reaction mixture is concentrated by distilling off the solvent. 1-Bromo-1-(4-chlorophenoxy)-5-chloro-3,3-dimethyl-pentan-2-one is obtained quantitatively, that is to say 177 g, and is directly reacted further. ##STR31##

Workup

  1. concentrationthe reaction mixture is concentrated
  2. distillationby distilling off the solvent

Sources & evidence

ORD record
ord-ac54c203549f47bea49de8622ec6b322
Source dataset
uspto-grants-1984_12
Patent number
US04487776

Reaction notes

Loading…