反应详情

To a refluxing solution of 15.0 g of 6-[2-(1-pyrrolidinyl)ethylamino]-7,8,9,10-tetrahydro-1,2,4-triazolo[3,4-a]phthalazine in 45 ml of ethanol was slowly added a solution of 13.2 g of phosphoric acid in an equal volume of ethanol. An exothermic reaction with vigorous foaming took place. The resulting slurry was refluxed for 1 hour and then cooled. The solid was separated by filtration, washed with ethanol and with absolute ethanol, and then dried at 50° C. under reduced pressure to give 6-[2-(1-pyrrolidinyl)ethylamino]-7,8,9,10-tetrahydro-1,2,4-triazolo[3,4-a]phthalazine diphosphate.

1. customAn exothermic reaction with vigorous foaming
2. temperatureThe resulting slurry was refluxed for 1 hour
3. temperaturecooled
4. customThe solid was separated by filtration
5. washwashed with ethanol and with absolute ethanol
6. customdried at 50° C. under reduced pressure