Water → HCID 13365597, compound

HRID 1154019Notes

Reaction equation

HRID 1154019 reaction equation
Cl[C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[C:5]2=[N:12][N:13]=[C:14]([CH3:15])[N:4]2[N:3]=1.[NH2:16][CH2:17][CH2:18][N:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1.O>COCCO>[CH3:15][C:14]1[N:4]2[N:3]=[C:2]([NH:16][CH2:17][CH2:18][N:19]3[CH2:23][CH2:22][CH2:21][CH2:20]3)[C:11]3[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=3[C:5]2=[N:12][N:13]=1

Participants

5

Reactant 3

HCID 962WaterHCID 13441-PyrrolidineethanamineHCID 20436005HCID 20436005, compound

Product 1

HCID 13365597HCID 13365597, compound

Reagents, catalysts & solvents 1

HCID 80192-MethoxyethanolSolvent

Procedure

A solution of 10.0 g of 6-chloro-3-methyl-7,8,9,10-tetrahydro-1,2,4-triazolo[3,4-a]phthalazine and 12.8 g of 1-(2-aminoethyl)pyrrolidine in 50 ml of 2-methoxyethanol was heated at reflux for 15 hours. The reaction mixture was poured into 150 ml of cold water and the white precipitate which formed was separated by filtration and air dried to give 3-methyl-6-[2-(1-pyrrolidinyl)ethylamino]-7,8,9,10-tetrahydro-1,2,4-triazolo[3,4-a]phthalazine melting at about 184°-186° C.

Workup

  1. temperatureat reflux for 15 hours
  2. customthe white precipitate which formed
  3. customwas separated by filtration and air
  4. customdried

Sources & evidence

ORD record
ord-459a5f4000174db292122a3103638ea7
Source dataset
uspto-grants-1984_12
Patent number
US04487930

Reaction notes

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