Stannous Chloride → HCID 178502043, compound

HRID 1154025Notes

Reaction equation

HRID 1154025 reaction equation
Cl.[CH3:2][O:3][C:4]([NH:6][C:7]1[NH:11][C:10]2[CH:12]=[CH:13][C:14]([S:16](Cl)(=O)=O)=[CH:15][C:9]=2[N:8]=1)=[O:5].Cl[Sn]Cl>O>[CH3:2][O:3][C:4]([NH:6][C:7]1[NH:11][C:10]2[CH:12]=[CH:13][C:14]([SH:16])=[CH:15][C:9]=2[N:8]=1)=[O:5]

Participants

4

Reactant 2

HCID 24479Stannous ChlorideHCID 178502050HCID 178502050, compound

Product 1

HCID 178502043HCID 178502043, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

10.8 g. (0.033 moles) of 2-[(Methoxycarbonyl) amino]-1H-benzimidazole-5-sulfonic acid chloride hydrochloride are suspended in 35 ml. of water, 33 g. of SnCl2 are added and the mixture is stirred at 50° C. for 30 minutes. A clear solution is obtained and then the precipitation of a crystalline substance can be observed. The mixture is cooled to room temperature, filtered and the precipitate is washed with a small portion of ice water. 2-[(Methoxycarbonyl)amino]-1H-benzimidazole-5-thiol obtained is further treated as described in Example 6 to yield 5 g. of the title compound, melting at 210° C.

Workup

  1. customA clear solution is obtained
  2. customthe precipitation of a crystalline substance
  3. temperatureThe mixture is cooled to room temperature
  4. filtrationfiltered
  5. washthe precipitate is washed with a small portion of ice water

Sources & evidence

ORD record
ord-40edf745dc54498eb9e2ac4e65bcb930
Source dataset
uspto-grants-1984_12
Patent number
US04487936

Reaction notes

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