2,4-Pentadienoic acid, methyl ester → HCID 20435937, compound

HRID 1154043Notes

Reaction equation

HRID 1154043 reaction equation
[CH2:1]([C:8]1([CH2:15][CH2:16][O:17][CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][O:19]2)[C:12](=[O:13])[NH:11][NH:10][C:9]1=[O:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:24]([O:30][CH3:31])(=[O:29])[CH:25]=[CH:26][CH:27]=[CH2:28]>>[CH2:1]([C:8]1([CH2:15][CH2:16][O:17][CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][O:19]2)[C:12](=[O:13])[N:11]2[CH2:28][CH:27]=[CH:26][CH:25]([C:24]([O:30][CH3:31])=[O:29])[N:10]2[C:9]1=[O:14])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 736882,4-Pentadienoic acid, methyl esterHCID 20435951HCID 20435951, compound

Product 1

HCID 20435937HCID 20435937, compoundYield 34%

Procedure

In a manner analogous to that described in Example 7(B) (b), from 2.7 g of 4-benzyl-4-[2-(tetrahydro-2-pyranyloxy)ethyl]pyrazolidine-3,5-dione and 1.05 g of methyl penta-2,4-dienoate there were obtained 1.2 g (34%) of methyl 2-benzyl-2,3,5,8-tetrahydro-1,3-dioxo-2-[2-(tetrahydro-2-pyranyloxy)ethyl]-1H-pyrazolo[1,2-a]pyridazine-5-carboxylate in the form of a white solid having a melting point of 113°-114° C. (from diethyl ether).

Sources & evidence

ORD record
ord-44f2b950700c4ef190b029a4e463f4d6
Source dataset
uspto-grants-1984_12
Patent number
US04487929

Reaction notes

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